Connecting the intestinal flora and drug targets, the tryptophan metabolism Kit is launched

- Oct 09, 2020-

Tryptophan metabolism product introduction


Tryptophan metabolism is regulated by the intestinal flora, and its metabolites have nerve, metabolism, and immune regulation functions, which affect human health and diseases. At the same time, the tryptophan metabolic pathway is also considered as a general therapeutic target for many diseases such as tumors, neurodegenerative diseases, and metabolic diseases. Therefore, tryptophan metabolism truly penetrates the intestinal flora and drug targets.

Aiming at the tryptophan metabolism pathway, Zhongke New Life provides a mature test product-tryptophan metabolism kit. This product has established cooperation with more than 10 domestic units, and the number of test samples exceeds 1000+. The features of the product are as follows:


High-depth coverage: 25 detection indicators, high-depth coverage of 3 metabolic pathways of tryptophan

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Gold standard method: Establish a targeted detection method for target analytes based on mass spectrometry, with high specificity, high sensitivity, high coverage and sensitivity as low as ng/g


Quantitative standard: Isotope internal standard correction to obtain accurate absolute content


Wide range of applications: suitable for detection of various sample types such as serum/plasma, tissue, stool, and cells.


Fast delivery: It only takes 13 working days to turn samples into experimental data.


Significance


The three most studied metabolites related to host-bacterial interaction are short-chain fatty acids, bile acids, and tryptophan (Trp) metabolites. Among them, tryptophan metabolites come from three metabolic pathways of tryptophan, such as the aryl hydrocarbon receptor pathway (AhR pathway), the kynurenine pathway (Kynurenine Pathway) and the serotonin pathway (Serotonin Pathway), which are involved Important biological functions such as immunity, neuronal function and intestinal homeostasis.

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Tryptophan metabolite function


In addition, tryptophan metabolism is a common therapeutic target for cancer, nervous system diseases, infectious diseases, autoimmune diseases and other diseases. Especially the rate-limiting enzymes in the metabolic pathway, indoleamine-2,3-dioxygenase 1 (IDO1), indoleamine-2,3-dioxygenase 2 (IDO2), tryptophan-2,3 -Dioxygenase (TDO) and kynurenine monooxygenase (KMO) are currently the targets of many drugs.

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Drug targets for tryptophan metabolism


Application case recommendation


Recent studies have shown that various types of diseases involve abnormalities in tryptophan metabolic pathways, so tryptophan metabolic pathways have gradually become drug targets and new opportunities for marker research.