Zhang Hui's team at Sun Yat-sen University has developed a new coronavirus nanoparticle vaccine

- Dec 21, 2020-

Sun Yat-sen University reported on the evening of the 26th that the top international immunology journal "Immunity" published on November 25, Beijing time the results of Professor Zhang Hui's research team from the Institute of Human Virology of Sun Yat-sen University in developing a new type of nanoparticle vaccine against the new coronavirus. The research team found that nanoparticle coupling can significantly enhance the protective immune response of protein vaccines. Currently, this nanoparticle vaccine is applying for clinical approval to the State Food and Drug Administration.

According to the article, the neutralizing antibody titer against the new coronavirus induced by this nanoparticle vaccine in mice ranks first in the world, and the neutralizing antibody titer induced in rhesus monkeys ranks third in the world. Although each laboratory has different detection methods and experimental sensitivity, it can still reflect the high titer of the nanoparticle vaccine.

Zhang Hui, director of the Institute of Human Virology, Sun Yat-sen University, said that unlike previous inactivated vaccines, attenuated vaccines and adenovirus vaccines, which have very mature technical routes, the nanoparticle vaccine is a multi-antigen recombinant protein vaccine that can be implemented in a single The surface of the nano vaccine simultaneously displays 24 identical or different new coronavirus antigens.

Zhang Hui’s team performed a wild-type SARS-CoV-2 respiratory tract infection on a humanized mouse model immunized with the nanoparticle vaccine. It was found that the lungs of the unimmunized mice were severely damaged, the virus replicated rapidly, and some mice They died three days after infection. The mice immunized with the nanoparticle vaccine are in good health, with no lung damage, and no residual virus can be detected in 11 organs and tissues including the lung. It can be seen that the neutralizing antibodies induced by the nanoparticle vaccine can significantly protect the body from the new coronavirus infection.

  In terms of safety, the nanoparticle vaccine developed by Sun Yat-sen University has relatively high safety. Experimental results showed that the nanoparticle vaccine did not cause side effects such as damage to other organs and organs in mice. The team also tested whether the antibodies induced by the mice may cause antibody-dependent infection enhancement (ADE). The results found that the antibodies induced by the nanoparticle vaccine There is no ADE effect.

   According to reports, "Immunity" was founded in 1994, and it is the immunology journal with the highest impact factor under Cell Press.

"The team's research and development process was extremely difficult. It took 161 trials and errors within 3 months, and finally verified the effectiveness and safety of the vaccine on animals. This time it was recognized by the international academic community, and we are very pleased. The epidemic and vaccine research and development are the permanent solutions to eliminate public health security threats." Zhang Hui said.

   It is understood that the research project is supported by the National Science and Technology Major Project, the National Natural Science Foundation, the National Key R&D Program, the Guangdong Province Key Field R&D Program, and the China Postdoctoral Innovative Talent Support Program.