A Collection Of 86 Chinese, Scholar And Science Articles By Chinese Scholars In 2019

- Nov 19, 2019-

Article published in April-June

[1] On June 21, 2019, Wang Wen of Northwestern Polytechnical University, Kunming Institute of Zoology, Chinese Academy of Sciences/BGI Zhang Guojie and Rasmus Heller of Copenhagen University of Denmark jointly published in Science Online entitled "Large-scale ruminant genome sequencing provides insights into their evolution". And distinct traits' research papers, which provide data not only for understanding the origin and evolution of ruminant populations and their specific traits, but also for the purpose of placing ruminant livestock genomic resources in evolutionary context and protecting ruminant biodiversity. ;

[2] Wang Wen, Northwestern Polytechnical University, Qiu Qiang, and Li Zhipeng, Institute of Special Products, Chinese Academy of Agricultural Sciences, published a research paper entitled "Biological adaptations in the Arctic cervid, the reindeer (Rangifer tarandus)" in Science, which was selected as Cover story of this issue of Science. This result may provide insights related to human health, including how the genetic response of vitamin D in reindeer affects bone and fat metabolism and how genes affect circadian rhythm arrhythmias;

[3] Jiang Yu of Northwest A&F University, Wang Wen and Qiu Qiang of Northwestern Polytechnical University jointly published a research paper entitled "Genetic basis of ruminant headgear and rapid antler regeneration" on Science Online, which revealed the headband of ruminant Evolutionary, developmental, and histological origins and genetic mechanisms of antler regeneration. The identified genes and their unique mutations provide guidance for future headband development, functional studies of mammalian organ regeneration and tumorigenesis;

[4] On June 14, 2019, Yang Maojun Science Journal of Life Science College of Tsinghua University published a research paper entitled "Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1", which was analyzed by high performance cryo-electron microscopy. a 6.2 angstrom structure of a mammalian ATP synthase tetramer having a molecular weight of up to 2.8 million Daltons, and a complete (19 subunits), two states of ATP synthase monomers of 3.34 angstroms and 3.45 angstroms;

[5] On June 14, 2019, Yuan Zhen and UCLA of the Wuhan University jointly published a research paper entitled "Large-area graphene-nanomesh/carbon-nanotube hybrid membranes for ionic and molecular nanofiltration" in Science. Developed a large-area graphene-nano-mesh/single-walled carbon nanotube (GNM/SWNT) hybrid film; this film has excellent atomic thickness and excellent mechanical strength;

[6] On June 12, 2019, Zhou Huihui of the Institute of Advanced Technology of the Chinese Academy of Sciences, Xiang Peng of Sun Yat-Sen University, Yang Shihua of South China Agricultural University and Feng Guoping of the Massachusetts Institute of Technology jointly published in Nature online titled "Atypical behaviour and connectivity in A research paper by SHANK3-mutant macaques, which uses the CRISPR-Cas9 technology to mediate the creation of the SHANK3-mutant macaque model, while obtaining the F1 generation. This model for the first time reproduces the autism spectrum disorder (Phelan-McDermid syndrome) in non-human primates, laying a solid foundation for further study of the molecular mechanisms of autism spectrum disorders;

[7] On June 12, 2019, Wu Hao, Harvard Medical School, and Mao Youdong, from Peking University, published a research paper entitled "Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome" on Nature Online. The frozen electron microscope structure of inactive human NLRP3 complexed with NEK7 has a resolution of 3.8 Å. In summary, structural and functional studies have demonstrated that the NLRP3-NEK7 interaction determines the NEK7 requirement for NLRP3 inflammasome activation;

[8] On June 10, 2019, Yang Hui and Zhou Haibo of the Institute of Neuroscience of the Chinese Academy of Sciences, together with Guo Fan of Sichuan University and Li Yixue of Shanghai Institute of Nutrition, Chinese Academy of Sciences, published an article entitled "Off-target RNA mutation induced by DNA base editing and Its elimination by mutagenesis, a study that further validates the off-targeting of the BE3 and ABE DNA single-base editors at the RNA level, and proposes an optimization scheme for both systems, effectively reducing their RNA Off-target effect at the level;

[9] On June 5, 2019, Nanjing University, Wang Peng, Nie Yuefeng and Pan Xiaoqing jointly published a research paper entitled "Freestanding crystalline oxide perovskites down to the monolayer limit" on Nature, which synthesized high quality independence. Perovskite oxides, such as SrTiO3 (STO) and BiFeO3 (BFO) films, as thin as a single unit cell, can be transferred to any desired substrate, such as silicon wafers and porous carbon;

[10] On May 31, 2019, Du Jiangfeng and Rong Xing of the University of Science and Technology of China published a research paper entitled "Observation of parity-time symmetry breaking in a single-spin system" on Science Online. The result is the development and understanding of quantum. The singular nature of PT symmetric Hamiltonian in the system provides a starting point;

[11] On May 30, 2019, the Z. Hong Zhou team at the University of California, Los Angeles (the first unit of the University of Science and Technology of China, Liu Yuntao as the first author) published a title in the journal Nature "Cryo-EM structures of Herpes simplex virus type1 portal vertex and packaged genome", this work uses cryo-electron microscopy to first analyze the key mechanism of human herpesvirus genome packaging and the DNA genome structure of the virus, helping to prevent and control various diseases caused by herpes virus. And hope to transform herpes virus for targeted therapy;

[12] On May 31, 2019, the Pei Lijia Group of the School of Life Sciences of Peking University published a research paper entitled "Cysteine-rich peptides promote interspecific genetic isolation in Arabidopsis" on Science Online, which showed knocking of the entire AtLURE1 gene family. Except that it does not affect fertility, it indicates that AtLURE1-PRK6-mediated signaling is not required for successful fertilization within an Arabidopsis species. This research is conducive to future breeding work, and can increase the gene pool by adding desired agronomic traits to crop plants;

[13] On May 30, 2019, Yan Ning (Tsinghua University as the first communication unit) and Wu Jianping jointly published a research paper entitled "Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+ Channel" on Cell. The study reported a cryo-EM structure of the complex of Cav1.1 with the antagonistic drugs nifedipine, diltiazem and verapamil, with resolutions of 2.9 Å, 3.0 Å and 2.7 Å, respectively; Cav1.1 A cryo-electron microscope (cryo-EM) structure with a DHP agonist Bay K 8644 complex with a resolution of 2.8 Å;

[14] On May 30, 2019, the team of Lin Huikuan of Wake Forest University (the first unit was the National Biomedical Analysis Center, the first author was Zhang Weina) published on Cell Online entitled "Lactate Is a Natural Suppressor of RLR Signaling by A study by Targeting MAVS, which found that glycolysis inactivated during RLR activation acts as a barrier to the production of type I IFN following RLR activation. RLR-triggered MAVS-RIG-I recognizes that hijacking of hexokinase binds to MAVS, resulting in impaired mitochondrial localization and activation of hexokinase. Lactic acid acts as a key metabolite responsible for glycolytic-mediated inhibition of RLR signaling by directly binding to the MAVS transmembrane (TM) domain and preventing MAVS aggregation;

[15] On May 22, 2019, Liu Kaihui, a researcher at the School of Physics, Peking University, Academician Yu Dapeng, and Academician Wang Enge, and collaborators published an article entitled "Epitaxial growth of a 100-square-centimetre single-crystalhexagonal boron nitride monolayer on copper" on Nature Online. The research paper, for the first time in the world, uses the central inversion of the symmetry-broken single crystal copper substrate to realize the epitaxial preparation of the decimeter-grade two-dimensional single crystal hexagonal boron nitride. The growth mechanism is universal and can be extended to the preparation of large-area single crystals of other two-dimensional materials;

[16] On May 16, 2019, Gao Fu, Key Laboratory of Pathogenic Microorganisms and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Xie Zhengde, Beijing Children's Hospital Affiliated to Capital Medical University, and Wei Wensheng, Peking University, published a book entitled "Human Neonatal" on Cell Online. A research paper by Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B", which identifies a neonatal Fc receptor (FcRn) as a universal capsid receptor for a large number of EV-B viruses by CRISPR-Cas9 library screening. This study systematically dissects the different roles of Echo 6 attachment and husking receptors, which provides a structural basis for understanding the mechanisms of enterovirus entry. The discovery that FcRn as its receptor will improve the development of oncolytic therapeutics based on echovirus;

[17] On May 17, 2019, Wu Ruqian of Fudan University and W.Ho of the University of California, Irvine, published a research paper entitled "Probing and imaging spin interactions with a magnetic single-molecule sensor" on Science Online. The result paves the way for new nanoscale imaging capabilities based on magnetic single molecule sensors;

[18] On May 15, 2019, Li Chunlai, National Astronomical Observatory of the Chinese Academy of Sciences, Ren Xin and Liu Jianjun jointly published a research paper entitled "Chang'E-4 initial spectroscopic identification of lunar far-side mantle-derived materials" in Nature. The study used the No. 4 in-situ spectroscopy data to prove that there are deep materials mainly composed of olivine and low-lime pyroxene in the Antarctic-Aitken Basin (SPA) on the back of the Moon, in order to answer questions about long-term domestic and foreign scholars. The issue of the composition of plutonium provides direct evidence that will support the improvement of the lunar formation and evolution model;

[19] On May 9, 2019, Gao Fu, Key Laboratory of Pathogenic Microorganisms and Immunology, Institute of Microbiology, Chinese Academy of Sciences, and Gao Feng, Institute of Industrial Biotechnology, Chinese Academy of Sciences, jointly published on Cell Online entitled "Molecular Basis of Arthritogenic Alphavirus". Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein, a research paper that reported the crystal structure of free mouse MXRA8 (mMXRA8) and the cryo-electron microscopy structure of the complex between human MXRA8 (hMXRA8) and CHIKV E protein. This finding provides important information about the development of therapeutic strategies for those with arthritis-producing alphaviruses;

[20] Liu Xiangyu of Tsinghua University and Brian K. Kobilka of Stanford University jointly published a research paper entitled "Structural Insights into the Process of GPCR-G Protein Complex Formation" in Cell, which proposed 14 carboxy termini with Gαs. The structure of the amino acid complexed β2AR structure and the GDP-bound Gs heterotrimer. These structures provide evidence for the alternate interaction between β2AR and Gs, while suggesting that the active structure of β2AR is only stabilized by the 14 amino acids of GsCT. The structure may represent a conformational intermediate in the formation of a non-nucleotide β2AR-Gs complex and reveal a dynamic process of G protein activation;

[21] On May 10, 2019, the Baiyang Group of the Institute of Genetics and Development of the Chinese Academy of Sciences collaborated with JIC's Anne Osbourn Group on Science Online entitled "A specialized metabolic netwo